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KMID : 0648320080140010031
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Journal of The Korean Society of Hypertension
2008 Volume.14 No. 1 p.31 ~ p.38
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The Effect of Cilostazol to Arterial Stiffness in Patients with Hypertension
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Na Jin-Oh
Park Chang-Gyu
Suh Soon-Yong
Choi Cheol-Ung
Rha Seung-Woon
Kim Jin-Won
Kim Eung-Ju
Seo Hong-Seog
Oh Dong-Joo
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Abstract
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Background : Cilostazol is a potent antiplatelet agent that selectively inhibits phosphodiesterase III, and also it has beneficial effect to peripheral arterial disease with intermittent claudication, by direct vasodilative action. However the
effect of cilostazol on arterial stiffness is unclear. We investigated the effect of cilostazol on arterial stiffness by using
Pulse Wave Velocity (PWV).
Methods : From May, 2006, total 708 hypertension patients were examined PWV study. Of those, 86 patients were taking cilostazol at least 3 months before PWV study. The rest 622 patients did not take cilostazol. All value of each aortic PWV, arm PWV, leg PWV of all patients were measured by using PP-1000(Han-Byul ® Co.).
Result : In cilostazol group, mean period of taking medicine was 823 days (130~1390days). In baseline characteristics, cilostazol group was older than control group (63±8 vs 57±10 p<0.001), had higher proportion of diabetes mellitus (41.9% vs 32.5% p<0.001), and more frequently taking aspirin and lipid-lowering agent (50.0% vs 33.4% p=0.004, 52.3% vs 32.5% p<0.001 respectively). There was no difference between two groups in aortic PWV and arm PWV (7.73 vs 7.61m/sec p=0.475, 8.06 vs 8.32m/sec p=0.092 respectively). But, leg PWV was significantly higher in control group than cilostazol group(10.12 vs 9.73m/sec, p=0.029). Also, use of cilostazol was the independent variable of leg PWV by multiple regression analysis (=-0.075 p=0.047).
Conclusions : We found that cilostazol is more effective on lower extremity arterial stiffness than central arterial stiffness. This finding might be one of mechanism that cilostazol is effective in peripheral arterial disease. Further study will be needed whether effect of cilostazol on peripheral artery disease have related to these improvement of arterial stiffness of lower extremity.
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KEYWORD
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cilostazol, pulse wave velocity, arterial stiffness
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